Endocrine Abstracts

Medullary thyroid carcinoma (MTC) is a rare thyroid C cell malignant tumor that accounts for 3-4% of thyroid gland neoplasias. MTC may occur sporadically or be inherited. Hereditary MTC appears as part of the MEN 2 syndrome. Germ-line mutations of the RET proto-oncogene cause hereditary cancer, whereas somatic mutations are frequently present in sporadic disease. Currently, early MTC diagnosis followed by total thyroidectomy offers the only possibility of the cure of the disea...

Background and aims: There are consistent findings about increased prevalence of depressive disorders in diabetes. The aim of the study was to reveal prevalence of depression in patients (pts) with type 1 (DM1) and type 2 (DM2) diabetes.Materials and methods: Totally, 157 pts with DM were questioned. To assess depression degree Beck’s scale was used, and 83 depressive pts (scores>10), were allocated into 2 groups (Gr.): Gr.1 (n=44)-DM2 pt...

Background: Neuroendocrine tumor (NET) symptoms are often similar to common conditions or may not arise until metastasis occurs, delaying diagnosis and impacting survival. We present data on time to diagnosis from the European (EU) NET patient perspective.Methods: In 2014, 1928 NET patients from >12 countries (Europe (n=763): Belgium, Bulgaria, France, Germany, Norway, UK, and other EU countries (not specified); Americas; Asia; Oceania) part...

Background: NETs are a rare heterogeneous group of malignancies, often with a delayed diagnosis. Although diagnosis of NETs is increasing (due in part to greater awareness), little has been published on the NET patient experience. We present data on the EU NET patient perspective.Methods: In 2014, 1928 NET patients from >12 countries, including EU (n=763: Belgium, Bulgaria, France, Germany, Norway, UK, other EU countries (not specified by re...

Introduction: Myxedema coma is the ultimate stage of severe long-standing hypothyroidism, representing a true endocrinological emergency. Many precipitating factors have been identified, including the initiation of certain drugs.Case report: An 89-year-old woman was admitted to our emergency department due to an inaugural seizure. There was a history of progressive functional deterioration in the last 7 weeks, short after being diagnosed with lymph node ...

Background: Cranial diabetes insipidus (DI) is characterised by the inability to produce vasopressin leading to uncontrolled diuresis. Management includes administering synthetic vasopressin analogue desmopressin (DDAVP). Recently, there have been several national reports of DDAVP omission causing serious patient harm. This study aims to evaluate the feasibility of an automated alert system using Natural Language Processing (NLP) in electronic health records (EHR) to detect DI...

Introduction: Hypercalcemia is not uncommon in clinical practice and may present as a life-threatening emergency. Its main aetiologies are primary hyperparathyroidism (80% parathyroid adenomas; 20% multiglandular hyperplasia, <1% parathyroid carcinomas) and hypercalcemia of malignancy, with or without presence of bone metastases.Case Report: We present a case of a 77 years-old male, submitted to a subtotal gastrectomy at the age of 73 due to a perfor...

Introduction: The ATA guidelines 2015 suggests lobectomy as an option for low risk thyroid tumors between 1–4 cm, although there remains some controversy once some characteristics become apparent only on pathologic examination.Objective/methods: Retrospective analysis of patients who underwent thyroid surgery in 2014 and 2015, with a histologic diagnosis of WDTC 1–4 cm in size and revision of the proportion of patients eligible for lobectomy wi...

Introduction: The economic burden of obesity on healthcare systems is increasing. Bariatric surgery leads to considerable weight loss and health improvement. However, this surgery is costly and doubts about its affordability have been raised. Few studies have assessed outcomes such as drug use and costs after bariatric surgery. The aim of this study was to evaluate drug consumption and costs before and after bariatric surgery.Methods: Retrospectively, da...

Case 1: A 65-year-old man was admitted with symptomatic hypocalcaemia (corrected calcium of 1.65 mmol/l, PTH 46.6 (1.6–6.8) pmol/l, and vitamin D 51.4 (50–150) nmol/l)) 5 days following denosumab initiation. He had a diagnosis of probable urothelial carcinoma with associated osteoblastic metastases, and 10 days prior to this admission had been treated for hypercalcaemia (corrected calcium of 3.04 (2.20–2.60) mmol/l) with i.v. fluids following which denosumab was...